Peptides
Semax Peptide: Benefits & Dosages
Dosage calculator available
Reconstitution & dosing math for Semax.
Semax is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) that enhances cognitive function, supports neuroprotection, and elevates mood through BDNF upregulation and neurotransmitter modulation. Developed in Russia in the 1980s and approved there for treating ischemic stroke, cognitive decline, and optic nerve disease.
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Quick Facts
| Quick Facts | Details |
|---|---|
| Compound Type | Synthetic ACTH-derived heptapeptide |
| Amino Acid Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Primary Mechanisms | BDNF upregulation, neurotransmitter modulation, melanocortin receptor activity |
| Key Effects | Cognitive enhancement, neuroprotection, mood elevation, potential athletic performance benefits |
| Administration | Intranasal (spray or drops) |
| Regulatory Status | Approved in Russia/Ukraine; NOT FDA-approved |
| Enhanced Analogue | N-Acetyl Semax Amidate (NASA) - improved stability and potency |
| Risk Level | Low-Moderate; well-tolerated in clinical settings |
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Semax Dosage
Dosage by goal (reconstructed from the values stated in the source).
| Goal | Dose |
|---|---|
| Cognitive enhancement | 300–600 mcg/day (Classic) · 200–400 mcg/day (NASA) |
| Ischemic stroke | 600 mcg–3 mg/day |
| Optic nerve | 600 mcg–1 mg/day |
| Mood | 300–600 mcg/day |
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Cycling
Typical cycle: 5 days on, 2 days off.
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Storage
Refrigerate at all times once reconstituted. Protect from heat and direct light. Nasal spray formulations may have shorter shelf lives than lyophilized powder.
This profile is being expanded — additional sections from the source are still being added.
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